Recently, the front cover of the internationally renowned academic journal Angewandte Chemie International Edition published the latest research progress in the field of renewable resource utilization by Professor Xu Ping of the School of Life Science and Technology, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University. Temperature-directed biocatalysis for the sustainable production of aromatic aldehydes or alcohols". Tao Fei's associate researcher is the co-correspondence author, postdoctoral Ni Jun and master's student Gao Yu as co-first authors. Lignin is the second most abundant biomass resource on Earth and the only renewable aromatic resource. Compared with traditional chemical materials, bio-based polymer is a new type of environmental protection material, which is the focus of the development of modern bio-manufacturing industry and the hot industry direction of global economic growth. The addition of aromatic units (aromatic aldehydes/alcohol monomers) to the bio-based polymer backbone can increase the hardness, hydrophobicity, and fire-retardant properties of the polymer, so the use of lignin resources that can be produced in raw materials has attracted scientists from all over the world. extensive attention. The variety and number of alcohol dehydrogenases in microbial cells can cause numerous side reactions, affecting the catalytic conversion efficiency of aromatic compounds and thus affecting the popularization and application of this method. The identification and knockout of many endogenous alcohol dehydrogenases in host cells is a huge challenge, and there is an urgent need to develop a new method to eliminate host endogenous alcohol dehydrogenase activity and allow aromatic aldehydes to accumulate. The research team innovatively introduced the aromatic aldehyde synthase gene of thermophilic bacteria into an intermediate-temperature host and constructed a temperature-oriented whole-cell catalytic system. At low temperatures, the catalytic system can convert feruloic acid, a renewable resource, into vanillyl alcohol under the combined action of exogenous enzymes and endogenous alcohol dehydrogenases; with the increase of temperature, endogenous alcohol dehydrogenases The activity is inhibited, while the functional enzyme activity derived from thermophile is maintained, and ferulic acid is efficiently converted to the corresponding aromatic aldehyde vanillin. Subsequently, based on the same strategy, the corresponding aromatic aldehyde/aromatic alcohol was synthesized using various cinnamic acid derivatives as substrates. This entirely new strategy avoids the cumbersome process of knocking out host endogenous alcohol dehydrogenases. The direct use of temperature controls the synthesis of aromatic aldehydes/aromatic alcohols, greatly simplifies the production process, and can be extended to many other aldehydes. The synthesis of compounds with aldehydes as intermediates has important practical significance and industrial application value. The research work was supported by projects supported by the National Natural Science Foundation of China (21777098, 31570101), the Shanghai Youth Science and Technology Talents Sailing Plan (17YF1410300) and the Shanghai Pujiang Talent Plan (15PJD019). Stainless Steel Cutting Board Rack
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